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Designing novel candidates as potential antibacterial scaffolds has become crucial due to the lack of new antibiotics entering the market and the persistent rise in multidrug resistance. Here, we describe a new class of potent antibacterial agents based on a 5‐aryl‐N2,N4‐dibutylpyrimidine‐2,4‐diamine scaffold. Structural optimization focused on the 5‐aryl moiety and the bioisosteric replacement of...
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