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Measles infection and vaccine response are complex biological processes that involve both viral and host genetic factors. We have previously investigated the influence of genetic polymorphisms on vaccine immune response, including measles vaccines, and have shown that polymorphisms in HLA, cytokine, cytokine receptor, and innate immune response genes are associated with variation in vaccine response...
There are no data currently available on gender and racial variation in smallpox vaccine immune responses. We recruited 1076 healthy adults 18–40 years old who received one dose of the US-licensed smallpox vaccine (Dryvax ® ). Vaccinia neutralizing antibody titers in each subject's serum were determined using a high throughput neutralization assay based on a recombinant, β-gal expressing vaccinia...
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