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Gd-Tex (gadolinium texaphyrin) is a radiation sensitizer that is selective for tumors and is detectable by magnetic resonance imaging (MRI). The objective of this multi-center phase Ib/II trial is to determine the maximum tolerated dose (MTD), response rate at MTD, dose limiting toxicities, pharmacokinetics and biolocalization as determined by MRI. Treatment consisted of a conventional dose of radiation...
Purpose: This article describes our technique of localization and implantation of the lumpectomy site of patients with T1 and T2 breast cancer. Our method was developed as part of our Phase I/II pilot study of high dose rate (HDR) brachytherapy alone after conservative surgery for early breast cancer.Methods and Materials: In March 1992, we started a pilot study of HDR brachytherapy to the lumpectomy...
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