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Purpose: These studies were designed to examine radiation-induced in-field and out-of-field DNA damage in rat lung as a function of dose and various volumes of irradiation. They also determined whether superoxide dismutase (SOD) and nitro-l-arginine methyl ester (l-NAME) protected against this damage.Methods and materials: The whole lung, or various volumes of the lower or upper lungs of Sprague–Dawley...
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