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Nebivolol is a novel beta1-selective beta-blocker with vasodilator properties mediated through activation of the l-arginine–nitric oxide pathway. There is no published report of coronary artery spasm associated with nebivolol. We describe a 64-year-old female patient who developed unstable angina secondary to nebivolol-induced vasospastic angina which was also visible during coronary angiography.
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