The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
DOTAP‐Functionalized Lipid Nanoparticles
In article number 2315721, Wooram Park and co‐workers introduce dual‐functional lipid nanoparticles (DLNPs) that enhance the antitumor efficacy of CAR‐NK cells by improving activation and mRNA delivery. DLNPs increase NK cell cytotoxicity via ERK/MAPK pathway modulation and mitochondrial dynamics changes. Glypican‐3‐targeting CAR‐NK cells fortified with DLNPs...
Natural killer (NK) cells are crucial in the innate immune response and show promise in cancer immunotherapy, but face challenges in activation and targeted gene delivery. In this study, bifunctional lipid nanoparticles (DLNPs) containing 1,2‐dioleoyl‐3‐trimethylammonium‐propane (DOTAP), designed to bolster the antitumor efficacy of chimeric antigen receptor‐modified NK (CAR‐NK) cells by facilitating...