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Background. Homocysteine (HCY) is an independent risk factor for atherosclerosis. This study is to investigate the effect of ginsenoside Rb1, a major constituent of ginseng, on HCY-induced endothelial dysfunction and molecular changes in porcine coronary arteries. Methods. Coronary arteries were harvested from pig hearts and cut into 5-mm rings, which were divided into 6 groups including control,...
Introduction. We previously reported that ritonavir (RTV), one of the clinically used HIV protease inhibitors, can cause endothelial injury by increasing oxidative stress. The objective of this study was to determine whether an active ingredient of Panax ginseng, Ginsenoside-Rb1 (Rb1), could prevent coronary arteries from RTV-induced vasomotor dysfunction. Methods. Porcine coronary arteries were cut...
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