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The immune system has a critical role in the recognition and suppression of neoplastic cells. First-generation immunotherapies have been used for decades with moderate success against a few tumor types. However, most such immunotherapies display a lack of either substantial efficacy or specificity, resulting in adverse events and, thus, have limited clinical use.Over the past few years, a better understanding...
Adenosine is a biologically active molecule that is formed at sites of metabolic stress associated with trauma and inflammation, and its systemic level reaches high concentrations in sepsis. We have recently shown that inactivation of A2A adenosine receptors decreases bacterial burden as well as IL-10, IL-6, and MIP-2 production in mice that were made septic by cecal ligation and puncture (CLP). Macrophages...
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