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The molecular mechanisms underlying hypoxic responses in pulmonary and systemic arteries remain obscure. Here we for the first time report that acute hypoxia significantly increased total PKC and PKCε activity in pulmonary, but not mesenteric arteries, while these two tissues showed comparable PKCε protein expression and activation by the PKC activator phorbol 12-myristate 13-acetate. Hypoxia induced...
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