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Non-dystrophic myotonic syndromes represent a heterogeneous group of clinically quite similar diseases sharing the feature of myotonia. These syndromes can be separated into chloride and sodium channelopathies, with gene-defects in chloride or sodium channel proteins of the sarcolemmal membrane. Myotonia has its basis in an electrical instability of the sarcolemmal membrane. In the present study we...
Objective: This investigation uses simulation studies to account for single muscle fiber waveforms with complex configurations as arising from the simultaneous recording of a partial intracellular discharge and its associated extracellular manifestation by way of an electrode-induced `rent' or tear in the sarcolemma. Methods: Published material on intracellular action potentials from healthy and 7...
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