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There is accumulating evidence that most β-lactam antibiotics (i.e., cephalosporins and penicillins) have some degree of convulsive activity, both in laboratory animals as well as in clinical settings. The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by γ-amino butyric acid (GABA) A -receptors (GABA A -R). However, comprehensive studies on...
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