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In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus–related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16INK4a immunohistochemistry (IHC) was also recommended to assist classification: block-like positive staining supports the diagnosis of HSIL....
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