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Stem cells are mainly characterized by two properties: self-renewal and the potency to differentiate into diverse cell types. These processes are regulated by different growth factors including members of the Wnt protein family. Wnt proteins are secreted glycoproteins that can activate different intracellular signaling pathways.Here we summarize our current knowledge on the role of Wnt/β-catenin signaling...
ES cells can self-renew while preserving pluripotency and are able to differentiate into many cell types. In both processes, different signal transduction pathways are implicated, including the Wnt/β-catenin pathway, which we here further analyzed. We found that a loss of β-catenin in ES cells leads to altered expression of stem cell marker genes. TCF/β-catenin reporter gene assays indicate that undifferentiated...
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