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Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical γ-aminobutyric acid (GABA) levels in male and female smokers. Healthy nicotine-dependent men (n = 10) and women (n = 6) underwent proton magnetic resonance spectroscopy (1H-MRS) to measure occipital cortex GABA concentrations. A subset of the smoking men (n = 5) underwent 1H-MRS scans...
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