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Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a central role in cellular defense against oxidative and electrophilic insults by timely induction of antioxidative and phase-2 detoxifying enzymes and related stress–response proteins. The 5′-flanking regions of genes encoding these cytoprotective proteins contain a specific consensus sequence termed antioxidant...
The present study was performed to evaluate the effects of two different phenolic antioxidants, resveratrol (3,5,4′-trihydroxystilbene) and butylated hydroxyanisole (BHA), on the hydrogen peroxide (H 2 O 2 )-induced inhibition of gap-junction intercellular communication (GJIC) in WB-F344 rat liver epithelial cells (WB-F344). Resveratrol is a naturally occurring polyphenolic antioxidant;...
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