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Schwann cell (SC) migration is an important step preceding myelination and remyelination in the peripheral nervous system, and can be promoted by peptide factors like neuregulins. Here we present evidence that a lipid factor, lysophosphatidic acid (LPA), influences both SC migration and peripheral myelination through its cognate G protein‐coupled receptor (GPCR) known as LPA1. Ultrastructural analyses...
Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA 1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive G i/o /phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced...
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