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microRNAs (miRNAs) are a class of small non-coding RNAs that deregulate and/or decrease the expression of target messenger RNAs (mRNAs), which specifically contribute to complex diseases. In our study, we reanalyzed an integrated data to promote classification performance by rebuilding miRNA–mRNA modules, in which a group of deregulated miRNAs cooperatively regulated a group of significant mRNAs....
Many microRNAs (miRNAs) are clustered on chromosomes and co-transcribed as polycistronic transcripts. Here, an integrated evolutionary analysis of human miRNA gene clusters and families was performed. Generally, miRNA gene clusters include 2–8 members, but some larger clusters have been found to have more members (over 40 miRNAs). 62.22% of them have been shown to be involved in homologous miRNA genes,...
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