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The ketogenic diet (KD) is an effective therapy for pediatric refractory epilepsies; however, whether the KD changes the pathologic network oscillations generated by an epileptic brain remains unknown. We have reported that hippocampal CA3 regions of epileptic Kv1.1α knockout (KO) mice generate pathologic sharp waves (SPWs) and high‐frequency oscillations (HFOs) that have higher incidence, longer...
In human disease, channelopathies involving functional reduction of the delayed rectifier potassium channel α-subunit K v 1.1 – either by mutation or autoimmune inhibition – result in temporal lobe epilepsy. K v 1.1 is prominently expressed in the axons of the hippocampal tri-synaptic pathway, suggesting its absence will result in widespread effects on normal network oscillatory activity...
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