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IL-6 plays important roles in regulation of liver functions and promotes hepatocarcinogenesis. As the contribution of IL-6-induced miRNAs to these effects is largely unknown, we investigate the effects of IL-6 on the miRNome of hepatoma cells and non-transformed hepatocytes. Moreover, little is known about miRNAs regulating key players of IL-6 signal transduction. Therefore, our aims were to identify...
The polymorphism at position 25 of the gene encoding transforming growth factor-β1 (TGF-β1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-β1 production. The homozygous genotype (Arg25Arg) is associated with higher TGF-β1 production than the heterozygous (Arg25Pro) genotype. Therefore, the possible involvement of this genetic...
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