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Downregulation of microRNA‐590‐3p (miR‐590‐3p) is a frequently occurring, nonphysiological event which is observed in several human cancers, especially breast cancer. However, the significance of miR‐590‐3p still remain unclear in the progression of this disease. This study explored the role of miR‐590‐3p in apoptosis of breast cancer cells. Gene expression of miR‐590‐3p, Sirtuin‐1 (SIRT1), Bcl‐2...
Nicotinamide adenine dinucleotide (NAD) is a critical coenzyme for all living cells. Nicotinamide phosphoribosyltransferase (NAMPT) functions as a key enzyme in the salvage pathway of NAD biosynthesis. Cancer cells have higher rate of NAD consumption and therefore NAMPT is essential for their survival. Thus, we investigated the effect of NAMPT inhibition by miR-206 on breast cancer cell survival....
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