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The tumor protein p53‐inducible nuclear protein 2 (TP53INP2) has been reported to participate in autophagy by interacting with autophagosome‐localized autophagy‐related protein 8 (Atg8) family proteins, including LC3. Here, we uncover a novel function for TP53INP2 in the autophagic degradation of proteins. We identify the ubiquitin‐interacting motif (UIM) of TP53INP2 that mediates its binding to ubiquitin...
Human MxA, an interferon‐inducible cytoplasmic dynamin‐like GTPase, possesses antiviral activity against multiple RNA viruses. Recently, MxA has also been demonstrated to have activity against the hepatitis B virus (HBV), a well‐known DNA virus responsible for acute and chronic liver disease in humans. We investigated the molecular mechanism for the anti‐HBV activity of MxA. Our results demonstrated...
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