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Several low fidelity DNA polymerases participate in generating mutations in immunoglobulin genes. Polymerase η is clearly involved in the process by causing substitutions of A:T base pairs, whereas polymerase ι has a controversial role. Although the frequency of mutations was decreased in the BL2 cell line deficient for polymerase ι, hypermutation was normal in the 129 strain of mice, which has a...
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