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Exon18 mutations are detected in 3.6% of epidermal growth factor receptor mutations. Exon 18 mutations as driver mutations have higher sensitivities in vitro to second‐generation (G)‐tyrosine kinase inhibitors (TKIs) than to first G‐ and third G‐TKIs at clinically relevant doses. In clinical trial, first G‐TKIs have moderate but insufficient efficacy, and afatinib was more active in uncommon epidermal...
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