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Recruitment of receptors at membrane interfaces is essential in biological recognition and uptake processes. The interactions that induce recruitment are typically weak at the level of individual interaction pairs, but are strong and selective at the level of recruited ensembles. Here, a model system is demonstrated, based on the supported lipid bilayer (SLB) that mimics the recruitment process induced...
Receptor Recruitment
Ligand‐functionalized lipid vesicles bind to receptor‐functionalized supported lipid bilayers through weak, multivalent receptor‐ligand interactions. As a result of binding, surface‐bound receptors move into the area of contact – a process called “recruitment” – to increase the local receptor density and thus enhance binding. The affinity, the size and the receptor density of...
Inspired by the action and healing process from living organisms, developing deployable devices using stimuli‐responsive materials, or “smart” deployable devices, is desired to realize remote‐controlled programmable deformation with additional in situ repair to perform multiple tasks while extending their service life in aerospace. In this work, a photoorganizable triple shape memory polymer (POTSMP)...
The inhibition of amyloid‐β (Aβ) aggregation by photo‐oxygenation has become an effective way of treating Alzheimer's disease (AD). New near‐infrared (NIR) activated treatment agents, which not only possess high photo‐oxygenation efficiency, but also show low biotoxicity, are urgently needed. Herein, for the first time, it is demonstrated that NIR activated black phosphorus (BP) could serve as an...
Ultrathin 2D inorganic nanomaterials are good candidates for lithium‐ion batteries, as well as the micro/nanocage structures with unique and tunable morphologies. Meanwhile, as a cost‐effective method, chemical doping plays a vital role in manipulating physical and chemical properties of metal oxides and sulfides. Thus, the design of ultrathin, hollow, and chemical doped metal sulfides shows great...
Efficient delivery of genes and therapeutic agents to the interior of the cell is critical for modern biotechnology. Herein, a new type of chemical‐free cell poration method—hypersonic poration—is developed to improve the cellular uptake, especially the nucleus uptake. The hypersound (≈GHz) is generated by a designed piezoelectric nano‐electromechanical resonator, which directly induces normal/shear...
In article number 1602962, Xuexin Duan and co‐workers, explore a novel chemical‐free cell poration method – “hypersonic poration”, which is developed to improve the cellular uptake, especially nucleus uptake, using a designed piezoelectric nanoelectromechanical resonator. The hypersound has a typical frequency larger than GHz, which can directly interact with the cell membrane and create reversible...
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