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AimTo investigate the effect of chronic H1‐antihistamine treatment on seizure susceptibility after drug withdrawal in nonepileptic rats and to further study its relation to glutamine synthetase (GS), which is the key enzyme for glutamate metabolism and gamma aminobutyric acid (GABA) synthesis.
MethodsAfter drug withdrawal from a 2‐week treatment with diphenhydramine or pyrilamine, seizure susceptibility...
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