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To evaluate the effects of letrozole on ovarian size and steroidogenesis in vivo, as well as on proliferation and steroidogenesis of theca-interstitial cells alone and in coculture with granulosa cells using an in vitro model.In vivo and in vitro studies.Research laboratory.Immature Sprague-Dawley female rats.In vivo effects of letrozole were studied in intact rats receiving either letrozole (90-day...
To evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells.In vitro study.Research laboratory.Immature Sprague-Dawley female rats.Granulosa cells were cultured in the absence or presence of resveratrol.DNA synthesis was determined by thymidine incorporation assay, apoptosis...
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