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To establish diagnostic performance of the cerebrospinal fluid (CSF) biomarkers β-amyloid peptide (Aβ 1–42 ), total tau-protein (T-tau) and tau phosphorylated at threonine 181 (P-tau 181P ) compared to clinical diagnosis, biomarker levels were determined in CSF samples from 100 autopsy-confirmed dementia and 100 control subjects. As the control and dementia groups were not age-matched...
CSF-Aβ42 may be a marker of Alzheimer's disease (AD). A decreased level of CSF-Aβ42 is consistently found in AD and has been suggested to be related to the deposition of amyloid plaques in the brain. However, low CSF-Aβ42 levels have also been found in disorders devoid of plaques, for instance Creutzfeldt–Jakob disease. To examine if the level of Aβ42 in CSF is related to inflammatory processes, we...
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