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It is difficult task to measure precisely the toxic effect of beta-amyloid (Aβ 1–42) peptides and also the protective effect of novel drug candidates against Aβ-peptides. The widely used MTT-assay in cell lines or primary cell cultures could be insensitive against Aβ-peptides.We describe here an easy and relevant method for testing Aβ 1–42 toxicity on acute hippocampal slices derived from rat. Brain...
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