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It is difficult task to measure precisely the toxic effect of beta-amyloid (Aβ 1–42) peptides and also the protective effect of novel drug candidates against Aβ-peptides. The widely used MTT-assay in cell lines or primary cell cultures could be insensitive against Aβ-peptides.We describe here an easy and relevant method for testing Aβ 1–42 toxicity on acute hippocampal slices derived from rat. Brain...
Reliable in vitro assays are essential for study of the effects of neurotoxic compounds such as β-amyloid peptides (Aβ). The MTT assay has been used in cultures of different cells, e.g. SH-SY5Y neuroblastoma cells, for the quantitative measurement of Aβ toxicity. In our laboratory differentiated SH-SY5Y cells were used in the MTT assay. Cell differentiation with 10μM all-trans-retinoic acid resulted...
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