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We have mapped the linear antigenic determinant of a commercial MAb raised in the mouse against the melanoma-associated-antigen Melan-A/MART-1. The B cell epitope on the Melan-A/MART-1 oncoprotein is located in the 15-mer amino acid sequence 101–115 PPAYEKLSAEQSPPP, within residues 102–106. The definition of the antigenic sequence on Melan-A/MART-1 oncoprotein was reached following analyses of MHC...
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