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Schizophrenia is a severe psychiatry disorder characterized by the positive and negative syndrome. Previous studies often treat the two syndromes independently. In our study, we proposed a multi-task regression and stability selection combined method to explore whether the two syndromes shared same brain functional deficits. 35 drug-naïve adolescent participants with first-episode schizophrenia were...
Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several...
Increasing evidence suggests that inflammation contributes to the etiology and progression of schizophrenia. Molecules that initiate inflammation, such as virus- and toxin-induced cytokines, are implicated in neuronal degeneration and schizophrenia-like behavior. Using therapeutic agents with anti-inflammatory or neurotrophic effects may be beneficial for treating schizophrenia. One hundred healthy...
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