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Achalasia is a disorder of esophageal motility characterized by esophageal aperistalsis and failure of the lower esophageal sphincter relaxation. The disease is progressive, resulting in gradual dilatation of the esophagus above the sphincter. Successful treatment of the disease by repeated esophageal bougienage was first described by Willis in 1674. Cardiomyotomy, the basis of modern surgical treatment...
Background Diffuse oesophageal leiomyomatosis (DOL) is a rare disorder characterized by tumorous overgrowth of the muscular wall of the oesophagus. DOL is present in 5 % of Alport syndrome (AS) patients. AS is a rare hereditary disease that involves varying degrees of hearing impairment, ocular changes and progressive glomerulonephritis leading to renal failure. In DOL-AS patients, the genetic defect...
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