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We hypothesize that Parkinson’s disease (PD) pathogenesis can be divided intothree temporal phases. During the first phase, ‘triggers’, such as viral infectionsor environmental toxins, spark the disease process in the brain and/or periph-eral tissues. Triggers alone, however, may be insufficient, requiring ‘facilitators’like peripheral inflammation for PD pathology to develop. Once the diseasemanifests,...
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