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A ninety-day toxicity study of semicarbazide hydrochloride (SEM-HCl) was conducted in male and female Wistar Hannover GALAS rats fed diet containing the compound at concentration of 0, 250, 500 and 1000ppm. Suppression of body weight gain and food consumption was found in both sexes at 1000ppm throughout the study. Enlargement and deformation of knee joints were obvious at 500 and 1000ppm from week...
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