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Preclinical evidence indicates an important role of adenosine (A) 2A receptors in drug addiction while their therapeutic relevance is still a matter of debate. We examined the influence of the A 2A receptor agonist CGS 21680 and the antagonist KW 6002 on nicotine sensitization and conditioned locomotor activity in adult (8-week old) male Sprague–Dawley rats (WT). Moreover, behavioral...
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