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Prodrugs that release hydrogen sulfide upon esterase‐mediated cleavage of an ester group followed by lactonization are described herein. By modifying the ester group and thus its susceptibility to esterase, and structural features critical to the lactonization rate, H2S release rates can be tuned. Such prodrugs directly release hydrogen sulfide without the involvement of perthiol species, which are...
Eine Serie von Thiosäuren wurde zu Schwefelwasserstoff‐Prodrugs entwickelt, die B. Wang et al. in ihrer Zuschrift auf vorstellen. Die H2S‐Freisetzung beruht auf einer Esterase‐vermittelten Spaltung, die eine Hydroxygruppe als angreifendes Nukleophil freilegt, das eine Lactonisierung bewirkt. Die Prodrugs sind unter physiologischen Bedingungen stabil, und die Geschwindigkeit der H2S‐Freisetzung kann...
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