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Complement deficient mice are resistant to experimental autoimmune myasthenia gravis (EAMG), suggesting a pivotal role for the membrane attack complex (MAC) in EAMG pathogenesis. To test the significance of MAC regulation in EAMG pathogenesis, CD59 KO and wild type mice were immunized with acetylcholine receptor (AChR). Interestingly, deletion of CD59, the regulator of MAC assembly, failed to augment...
The complement system is established as a major homeostatic system and a factor in diverse pathologies. Some 500 delegates attended a recent meeting1The XVIII International Complement Workshop was held at Snowbird, UT, USA, on 23-27 July 2000. 1 to discuss the latest findings in complement research, ranging from studies in sea squirts through to therapeutic trials of inhibitors. Here, we review...
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