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Intestinal mucosal immunity plays a pivotal role in host defence. In this study, we found that cluster of differentiation 226 (CD226) gene knockout (KO) led to more severe atopic dermatitis (AD)‐related skin pathologies and bowel abnormalities in a 2,4‐dinitrochlorobenzene (DNCB)‐induced AD‐like mouse model. Following DNCB administration, the expression of CD226 was elevated in intestinal mucosal...
The costimulation molecule CD226 is widely involved in T cell differentiation, activation and immune functional regulation in peripheral immune tissues. CD226‐deficient mice have impaired immune response capacity. The function of CD226 in regulating T cell development in the thymus, a central immune organ, is not yet fully understood. We investigated the development of thymocytes using CD226 knockout...
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