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MicroRNAs (miRNA) are small RNA molecules that negatively regulate gene expression through base pairing interactions between 3′‐UTR of the target mRNAs and seed sequence of miRNA. Any changes in the recognition site could destroy binding sites or modify binding affinity, resulting in evasion from miRNA regulation. A putative binding site for miR‐491‐5p resides in 3′‐UTR of MMP9, and a genetic variant...
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