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Src plays a critical role in regulating cellular responses induced by protease‐activated receptor 1 (PAR1). Here, we found that PAR1 activation induces lysosomal degradation of Src. Src is associated and trafficked together with activated PAR1 to early endosomes and then sorted to lysosomes for degradation. Blocking agonist‐induced endocytosis of PAR1 by inhibition of dynamin activity suppresses PAR1‐induced...
Tissue-transglutaminase (t-TGase) is a family of calcium-dependent enzymes. A Ca 2+ -independent soluble enzyme, in addition to t-TGase, capable of incorporating polyamines into proteins was demonstrated in rat intestinal mucosa. The Ca 2+ -independent enzyme was stimulated 2- to 5-fold by Fe 2+ and Co 2+ ions but inhibited by Cu 2+ ...
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