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Alterations in metabolism could be due to cell-autonomous effects associated with altered expression of Clock in central nervous system feeding centers and/or peripheral tissues involved in metabolism. Clock mutant mice are hyperphagic and obese, which indicates that Clock is related to obesity. In the present study, we used intracerebroventricular injection of recombinant adenoviral vector harboring...
Because most previous diffusion tensor imaging (DTI) studies have focused on late-life depression, this study examined the possible changes in brain white matter (WM) in first-episode, treatment-naive young adults with major depressive disorder (MDD). DTI was performed in 25 (10 males and 15 females) first-episode, treatment-naive young adult patients with MDD and 25 healthy controls matched for age,...
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