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To develop insulin delivery system for the treatment of diabetes, two insulin-loaded nanogels with opposite zeta potential (−15.94±0.449mV for insulin:CMCS/CS-NGs(−) and +17.15±0.492mV for insulin:CMCS/CS-NGs(+)) were obtained. Ex vivo results showed that the nanogels with opposite surface charge exhibited different adhesion and permeation in specific intestinal segments. There was no significant...
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