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Cell adhesion is one function regulated by cellular prion protein (PrP c ), a ubiquitous, glycosylphosphatidylinositol-anchored glycoprotein. PrP c is located in cell–cell junctions and interacts with desmosome proteins in the intestinal epithelium. We investigated its role in intestinal barrier function. We analyzed permeability and structure of cell–cell junctions in intestine...
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