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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links between upper‐ and lower‐airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic...
United airways disease (UAD) is the concept that the upper and lower airways, which are anatomically and immunologically related, form a single organ. According to this concept, upper and lower airway diseases are frequently comorbid because they reflect manifestations of a single underlying disease at different sites of the respiratory tract. Allergic asthma‐allergic rhinitis is the archetypal UAD,...
Background
The IL‐13 receptor α2 (IL‐13Rα2) is a receptor for IL‐13 which has conflicting roles in mediating IL‐13 responses in the lower airway, with little known about its impact on upper airway diseases. We sought to investigate the expression of IL‐13 receptors, IL‐13Rα1 and IL‐13Rα2, in chronically inflamed nasal epithelium, and explore IL‐13‐induced signaling pathways in an in vitro model of...
Background
The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes.
Methods
A total of 28 clinical variables and 39 mucosal cellular and molecular...
Background
The aim of this study was to investigate the prevalence of epidemiologic and physician‐diagnosed pollen‐induced AR (PiAR) in the grasslands of northern China and to study the impact of the intensity and time of pollen exposure on PiAR prevalence.
Methods
A multistage, clustered and proportionately stratified random sampling with a field interviewer‐administered survey study was performed...
We have previously shown that sensitizations to several types of allergens distinguish subjects with and without adult‐onset asthma in Finland. The aim was to analyze how age affects sensitization and asthma risk. We used previous population‐based case‐control data (N=456) from Finnish adult asthma patients with one or two matched controls. Asthma was diagnosed based on a typical history of asthmatic...
Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination...
Background
Aberrant epithelial remodeling with the ectopic expression of p63 (basal cell markers) is an important pathologic phenomenon seen in chronically inflamed airway epithelium such as in nasal polyps (NPs).
Methods
Biopsies were obtained from 55 NP patients and 18 healthy controls (inferior turbinate). Among NP patients, 15 were treated with oral and nasal steroids, so that two sets of NP...
BackgroundAllergic Rhinitis Control Test (ARCT) has been validated for assessing allergic rhinitis (AR) control and identifying severe AR. The aim of the study was to assess the ARCT questionnaire as a tool for stepwise pharmacotherapy.
MethodsA standard pharmacotherapy regimen from Step 1 (oral second‐generation H1 antihistamine as needed) to Step 5 (oral corticosteroid) was carried out prospectively...
Research efforts in allergic rhinitis have always been intense. Over the past 3 years, numerous breakthroughs in basic science and clinical research have been made, augmenting our understanding of this condition that afflicts a significant proportion of the global population. New epidemiological findings, novel insights into the molecular and cellular mechanisms of allergy, enhancement of current...
Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK‐rhinitis (MACVIA‐ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred...
BackgroundThere is a large global variation in the sensitization pattern and its association with allergic diseases. In temperate and tropical urban environments, mite monosensitization can be the predominant cause of allergic airway diseases, whereas in other environments, polysensitization is more typical. Sensitization to mite allergens associates with asthma. However, it is suggested that mite...
BackgroundSoutheast Asian populations are increasingly affected by allergic airway diseases. Etiology and specific causes, however, are still unknown. The aim of this study is therefore to identify allergens and risk factors for the high prevalence of allergic airway disease in the tropical urban environment.
MethodsSymptoms of allergic rhinitis (AR), asthma, and allergic dermatitis were recorded...
BackgroundWith the broad and increasing application of therapeutic monoclonal antibodies (mAbs) in clinical settings, IgG‐induced allergic reactions, including passive systemic anaphylaxis (PSA), have attracted significant attention. However, it is not clear which types of IgG mAb–antigen complexes or IgG aggregates formed by antigen binding can trigger PSA, as not all immune complexes (ICs) are capable...
BackgroundNasal polyposis (NP) is a Th2‐skewed inflammatory disorder, but it is unclear what role regulatory T cells (T‐reg) play in disease pathology. We investigated the expression profiles of T‐reg and T‐helper‐cell‐associated genes and their response to glucocorticosteroid (GC) treatment in Chinese patients with NP.
MethodsBiopsies were obtained from 29 non‐treated NP patients for comparison...
To cite this article: Tian L, Li W, Wang J, Zhang Y, Zheng Y, Qi H, Guo X, Zhang Y, Ma D, Shen H, Wang Y. The CKLF1‐C19 peptide attenuates allergic lung inflammation by inhibiting CCR3‐ and CCR4‐mediated chemotaxis in a mouse model of asthma. Allergy 2011; 66: 287–297.
AbstractBackground: Human chemokine‐like factor 1 (CKLF1) is a functional ligand for human CCR4, which is highly expressed on Th2...
To cite this article: Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao. Allergy 2011; 66: 101–109.
AbstractBackground: Horsefly bite can cause allergic reactions in humans. There is no information about allergenic horsefly proteins.Objectives: The current work...
To cite this article: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB. Opposing roles of IL‐17A and IL‐25 in the regulation of TSLP production in human nasal epithelial cells. Allergy 2010; 65: 581–589.
AbstractBackground: The importance of IL‐17A, IL‐17F, and IL‐25 in allergic rhinitis (AR), as well as their possible role in regulation on thymic stromal lymphopoietin (TSLP)...
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