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A microengineered hybrid hydrogel containing asymmetrical extracellular matrices is developed to mimic anisotropic stem cell niches, in work reported by Ali Khademhosseini and co‐workers on p. 5276. The reconstructed artificial asymmetrical extracellular matrix enables thorough investigation of spatially regulated embryonic development without exogenous factors. This technique may be a powerful platform...
A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene‐glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices around individual aggregate of mouse EBs induce polarity and demonstrate the potential of microscale engineered...
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