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Glu-Leu-Arg (ELR)-CXC chemokines are important in acute responses to bacterial infections, wherein neutrophils are often critical to pathogen clearance. However, excessive neutrophil recruitment augments the pathology of many diseases. We have shown that bovine CXCL8 (3–74) K11R/G31P (bG31P) is a highly effective ELR–CXC chemokine and neutrophil antagonist in cattle, but herein we wished to...
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