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Surface modification with polyethylene glycol (PEG) has been employed in the development of biomaterials to reduce unfavorable reactions. However, unanticipated body reactions have been reported, with activation of the complement system being suggested as having involvement in these responses. In this study, we prepared a PEG-modified surface on a gold surface using a monolayer of α-mercaptoethyl-ω-methoxy-polyoxyethylene...
Poly(ethylene glycol) (PEG) has been widely used for the preparation of biomedical devices and drug carriers to reduce the interaction of proteins with artificial materials. However, unanticipated body reactions such as hypersensitivity reactions caused by PEG-modified surfaces have been reported. Body reactions to PEG-modified materials still remain unclear. In this study, complement activation on...
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