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Nitroglycerin (NTG) is metabolized to nitric oxide (NO) in vascular smooth muscle cells. It has been suggested that prolonged exposure to NO results in reduced vascular sensitivity to NO and/or down regulation of NO synthesis. Whether such changes contribute to the in vivodevelopment of nitrate tolerance is currently not clear. This study investigates NO-mediated vasodilation in conscious rats before...
Nitroglycerin (NTG) is metabolized to nitric oxide (NO) in vascular smooth muscle cells. It has been suggested that prolonged exposure to NO results in reduced vascular sensitivity to NO and/or down regulation of NO synthesis. Whether such changes contribute to the in vivodevelopment of nitrate tolerance is currently not clear. This study investigates NO-mediated vasodilation in conscious rats before...
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