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Immunotherapy is a promising cancer therapeutic strategy. However, the “cold” tumor immune microenvironment (TIME), characterized by insufficient immune cell infiltration and immunosuppressive status, limits the efficacy of immunotherapy. Tumor vascular abnormalities due to defective pericyte coverage are gradually recognized as a profound determinant in “cold” TIME establishment by hindering immune...
Tumor Immunotherapy
Tumor vascular abnormalities is a profound determinant in the “cold” tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8‐RGD effectively induced tumor vascular normalization, by reprogramming the “cold” TIME to a “hot” tumor immune microenvironment and facilitated robust antitumor immunity. More in article number 2308638, Yongquan Qu, Jie...
The design and fabrication of NO‐evolving core‐shell nanoparticles (denoted as NC@Fe), comprised of BNN6‐laden COF@Fe3O4 nanoparticles, are reported. This innovation extends to the modification of 3D printed polyetheretherketone scaffolds with NC@Fe, establishing a pioneering approach to multi‐modal bone therapy tailored to address complications such as device‐associated infections and osteomyelitis...
Mechanically sensitive tissues (e.g., skeletal muscles) greatly need mechanical stimuli during the development and maturation. The extracellular matrix (ECM) mediates these signals through nonlinear viscoelasticity of collagen networks that are predominant components of the ECM. However, the interactions between cells and ECM form a feedback loop, and it has not yet been possible to determine the...
Diabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chronic inflammation, and increased susceptibility to infection. To tackle these challenges and provide a comprehensive therapeutic approach for diabetic wounds, the first coaxial electrospun nanocomposite membrane is developed...
Generating sufficient power from waste heat is one of the most important things for thermoelectric (TE) techniques in numerous practical applications. The output power density of an organic thermoelectric generator (OTEG) is proportional to the power factors (PFs) and the electrical conductivities of organic materials. However, it is still challenging to have high PFs over 1 mW m−1 K−2 in free‐standing...
Tailoring the interface between organic semiconductor (OSC) and ferromagnetic (FM) electrodes, that is, the spinterface, offers a promising way to manipulate and optimize the magnetoresistance (MR) ratio of the organic spin valve (OSV) devices. However, the non‐destructive in situ regulation method of spinterface is seldom reported, limiting its theoretical research and further application in organic...
A superior composite material consisting of MXene and ruthenium dioxide‐modified carbon cloth is synthesized by pulsed laser deposition and electrostatic self‐assembly, which is further utilized to construct a class of novel electrochemical (EC) sensors for kaempferol (KA) detection. The carbon‐cloth‐based electrodes modified by ruthenium dioxide and then MXene are characterized by X‐ray diffraction,...
Developing stable catalysts with higher selectivity and activity within a wide potential range is critical for efficiently converting CO2 to ethanol. Here, the carbon‐encapsulated CuNi nanoparticles anchored on nitrogen‐doped nanoporous graphene (CuNi@C/N‐npG) composite are designedly prepared and display the excellent CO2 reduction performance with the higher ethanol Faradaic effiency (FEethanol ≥...
Low conductivity over a wide temperature region due to ultra‐slow ion migration dynamics is a key issue in the field of solid‐state electrolytes (SSE), which needs to be solved and improved. Covalent organic frameworks (COFs), a rapidly growing class of porous crystalline materials, emerge as a new research hotspot in the field of SSEs. This is due to their homogeneously dispersed sites and well‐defined...
Albeit considerable attention to the fast‐developing organic thermoelectric (OTE) materials due to their flexibility and non‐toxic features, it is still challenging to design an OTE polymer with superior thermoelectric properties. In this work, two “isomorphic” donor–acceptor (D–A) conjugated polymers are studied as the semiconductor in OTE devices, revealing for the first time the internal mechanism...
Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount of reactive oxygen radicals (ROS) and DNA double‐strand breaks (DSBs), a fair number of them suffer from radiotherapy resistance and the subsequent short‐term survival opportunity. To overcome it, many successes have been achieved in radiosensitizer discovery using physical strategy and/or biological strategy,...
Biodegradable implantable devices are of growing interest in biosensors and bioelectronics. One of the key unresolved challenges is the availability of power supply. To enable biodegradable energy‐storage devices, herein, 2D heterostructured MoO3–MoS2 nanosheet arrays are synthesized on water‐soluble Mo foil, showing a high areal capacitance of 164.38 mF cm−2 (at 0.5 mA cm−2). Employing the MoO3–MoS...
Electrochemical Nc reduction has been regarded as one of the most promising approaches to producing ammonia under mild conditions, but there are remaining pressing challenges in improving the reaction rate and efficiency. Herein, an unconventional galvanic replacement reaction is reported to fabricate a unique hierarchical structure composed of Fe3O4‐CeO2 bimetallic nanotubes covered by Fe2O3 ultrathin...
Polyphosphate (polyP) is one of the most compact inorganic polyanionic biopolymers that participates in various physiological processes. However, the development of polyP‐based nanomaterials is still in its infancy. Here, biocompatible polyphosphate‐manganese nanosheets are designed and synthesized by a hierarchical assembly strategy. The thickness and the lateral size of the resulting polyP‐Mn nanosheets...
The electrocatalytic carbon dioxide reduction reaction (CO2RR) to value‐added chemical products is an effective strategy for both greenhouse effect mitigation and high‐density energy storage. However, controllable manipulation of the oxidation state and porous structure of Cu‐carbon based catalysts to achieve high selectivity and current density for a particular product remains very challenging. Herein,...
Luminescent Janus nanoparticles refer to a special category of Janus‐based nanomaterials that not only exhibit dual‐asymmetric surface nature but also attractive optical properties. The introduction of luminescence has endowed conventional Janus nanoparticles with many alluring light‐responsive functionalities and broadens their applications in imaging, sensing, nanomotors, photo‐based therapy, etc...
Water electrolysis affords a promising approach to large‐scale hydrogen yield, but its efficiency is restrained by the sluggish water dissociation kinetics. Here, an efficient bifunctional electrocatalyst of in situ formed crystalline nickel metaphosphate on amorphous NiMoOx nanoarrays supported on nickel foam (c‐Ni2P4O12/a‐NiMoOx/NF) for both hydrogen evolution reaction (HER) and oxygen evolution...
Resin derived hard carbons (HCs) generally demonstrate remarkable electrochemical performance for both sodium ion batteries (SIBs) and potassium‐ion batteries (KIBs), but their practical applications are hindered by their high price and high temperature pyrolysis (≈1500 °C). Herein, low‐cost pitch is coated on the resin surface to compromise the cost, and meanwhile manipulate the microstructure at...
Transition‐metal sulfides (TMSs) are attractive oxygen evolution reaction (OER) electrocatalysts. Developing new strategies to improve their electrochemical performance of TMSs is of great significance. Herein, a unique pacman‐like titanium‐doped cobalt sulfide hollow superstructure (Ti‐CoSx HSS) is fabricated as an OER electrocatalyst. Using a prearranged metal–organic framework (MOF)‐on‐MOF heterostructure...
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