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CD8+CD28− human T-suppressor cells (Ts), which can be generated in vitro, act directly on APC rendering them tolerogenic to unprimed and primed CD4+ T cells. The aim of this study was to investigate the possibility that CD8+ T cells mediate the induction of tolerance in a heart transplantation model in rodents. Blood from Lewis rats was UV-B–irradiated and transfused into ACI recipients on days...
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